🔗 - Google Scholar
🔗 - ORCID

📝 Publications

Manuscripts In Submission (* co-corresponding authors; # co-first authors)

• Du Y*, Dai H, Zhou J, Zhou Z, Yuan R, Ye R, Nguyen ATQ, Bhatia K, Lin SY.
  Chemotherapeutic induction of cytosolic single-stranded DNA accumulation sensitizes triple-negative breast cancer to immunotherapy.
  Journal for ImmunoTherapy of Cancer. In revision. (MD Anderson Cancer Center)

• Huang L#, Liu PP#, Du Y#, Pan DN, Chen QB, Wang YX.
  A novel adipokine suppresses leptin signaling and food intake.
  Nature Metabolism. In revision. (UMass Medical School)

Publications in Microbiology and Immunology

• Du Y#, Faz-Lopez B#, Ah Kioon MD, Cenac C, Pierides M, Lakin K, Spiera RF, Chaumeil J, Truchetet ME, Gordon JK, Guéry JC*, Barrat FJ* (2025).
  Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of plasmacytoid DCs in systemic sclerosis.
  The Journal of Experimental Medicine, 222(3): e20231809.

• Du Y, Ah Kioon MD, Laurent P, Chaudhary V, Pierides M, Yang C, Oliver D, Ivashkiv LB, Barrat FJ (2022).
  Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.
  The Journal of Experimental Medicine, 219(7): e20212142.

• Xiao X#, Du Y#, Sun S, Su X, Xing J, Wang G, Elzein SM, Zou D, Minze LJ, Mao Z, Ghobrial RM, Conner AA, Chen W, Zhang Z, Li XC (2024).
  Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models.
  Journal of Clinical Investigation, 135.

• Wang JY#, Lu WT#, Zhang J#, Du Y#, Fang ML, Xing JJ (2024).
  Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress and ROS responses in male mice.
  Nature Communications, 15: 3481.

• Ah Kioon MD#, Laurent P#, Chaudhary V#, Du Y#, Crow MK, Barrat FJ (2024).
  Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity.
  Immunological Reviews.

• Xiong D#, Du Y#, Wang HB#, Zhao B#, Zhang H, Li Y, Hu LJ, Cao JY, Zhong Q, Liu WL, et al. (2015).
  Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells.
  PNAS, 112: 11036–11041. (Part of my Ph.D. thesis)

• Chaudhary V, Mishra B, Ah Kioon MD, Du Y, Barrat F.
  Regulation of NRF2 in plasmacytoid DCs determines resolution versus fibrosis in the skin.
  The Journal of Experimental Medicine. Accepted.

• Cakan E, Ah Kioon MD, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Vega Loza A, Du Y, Schickel JN, Boeckers JM, et al. (2023).
  TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.
  The Journal of Experimental Medicine, 220.

• Yang C, Bachu M, Du Y, Brauner C, Yuan R, Ah Kioon MD, Chesi G, Barrat FJ, Ivashkiv LB (2022).
  CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
  Nature Communications, 13: 3426.

• Xia Y, Inoue K, Du Y, Baker SJ, Reddy EP, Greenblatt MB, Zhao B (2022).
  TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis.
  Nature Communications, 13: 3920.

• Xing J, Zhang A, Du Y, Fang M, Minze LJ, Liu YJ, Li XC, Zhang Z (2021).
  PARP9 is a noncanonical sensor for RNA virus in dendritic cells.
  Nature Communications, 12: 2681.

• Zhang A, Xing J, Xia T, Zhang H, Fang M, Li S, Du Y, Li XC, Zhang Z, Zeng MS (2020).
  EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells.
  EMBO Reports, 21: e49666.

• Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, et al. (2018).
  Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry.
  Nature Microbiology, 3.

• Ni C, Chen Y, Zeng M, Pei R, Du Y, Tang L, Wang M, Hu Y, Zhu H, He M, et al. (2015).
  In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures.
  Cell Research, 25: 785–800.

• Wang HB, Zhang H, Zhang JP, Li Y, Zhao B, Feng GK, Du Y, Xiong D, Zhong Q, Liu WL, et al. (2015).
  Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
  Nature Communications, 6: 6240.

Publications in Cancer Biology

• Du Y#, Liu L#, Wang C#, Kuang B, Yan S, Zhou A, Wen C, Chen J, Wu Y, Yang X, et al. (2016).
  TACC3 promotes colorectal cancer tumourigenesis and correlates with poor prognosis.
  Oncotarget, 7: 41885–41897.

• Du Y#, Yan SM#, Gu WY, He F, Huang LY, Li M, Yuan Y, Chen RH, Zhong Q, Li MZ, et al. (2015).
  Decreased Expression of FADS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma.
  Asian Pacific Journal of Cancer Prevention, 16: 5089–5094.

• Dai DN#, Li Y#, Chen B#, Du Y#, Li SB, Lu SX, Zhao ZP, Zhou AJ, Xue N, Xia TL, et al. (2017).
  Elevated expression of CST1 promotes breast cancer progression and predicts poor prognosis.
  Journal of Molecular Medicine, 95: 873–886.

• Yuan Y#, Du Y#, Hu XY, Liu MY, Du JK, Liu XM, Yu HE, Wang TZ, Pu JX, Zhong Q, et al. (2017).
  Longikaurin A suppresses stemness in nasopharyngeal carcinoma cells.
  Oncology Letters, 13: 1672–1680.

• Chen RH#, Du Y#, Han P, Wang HB, Liang FY, Feng GK, Zhou AJ, Cai MY, Zhong Q, Zeng MS, et al. (2016).
  ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma.
  Oncotarget, 7: 16910–16922.

• Li RC#, Du Y#, Zeng QY#, Tang LQ, Zhang H, Li Y, Liu WL, Zhong Q, Zeng MS, Huang XM (2016).
  Antibodies Against EBV gp42 for Diagnosis of Nasopharyngeal Carcinoma.
  Clinical Laboratory, 62: 553–561.

• Li RC#, Du Y#, Zeng QY#, Tang LQ, Zhang H, Li Y, Liu WL, Zhong Q, Zeng MS, Huang XM (2016).
  EBV gH/gL antibodies complement IgA-VCA for NPC diagnosis.
  Oncotarget, 7: 16372–16383.

📜 Patent

• Wang YX, Huang L, Du Y (2019).
  Methods for improving leptin sensitivity for the treatment of obesity and diabetes.
  WO/2019/21770.