Welcome to the Du Lab in Shenzhen University Basic Medical School.
We are a research group exploring the complex interplay between the immune system and disease. Our work bridges fundamental immunology and translational applications in autoimmunity, infection, and cancer.
Research Interests:
The Du laboratory studies the mechanisms that regulate nucleic acid sensing and type I interferon–driven immunity. We are particularly interested in how extracellular nucleic acids are delivered into immune cells and how this process controls interferon responses in inflammation, autoimmunity, and cancer immunotherapy.
Our research integrates molecular immunology, biochemistry, and cell biology with multi-omics and bioinformatics approaches. We combine CRISPR-based functional genomics, single-cell RNA sequencing, ATAC-seq, and other omics technologies to identify key regulators of nucleic acid uptake and innate immune signaling and to understand how these pathways shape immune cell phenotypes.
Our long-term goal is to bridge fundamental immunology with translational research by developing strategies that achieve selective immune modulation—suppressing pathogenic inflammation while preserving protective immunity—and ultimately translating these insights into new therapeutic approaches that benefit patients.
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📧 For inquiries: duyongfnp@szu.edu.cn